SAMe 200

Versatile nutrient supports mood regulation, joints, and liver function


As a modulator of neurochemical activity, and the most active endogenous methyl donor, S-Adenosyl L-Methionine (SAMe) supports a host of energy-requiring processes within the body, promoting healthy mood, cognition, and emotional well-being. In numerous controlled clinical trials, SAMe has been shown to support joint comfort and mobility, cellular detoxification and liver function, and healthy bile flow during pregnancy. Each tablet of Klaire Labs®’ SAMe 200 contains 200 mg of elemental SAMe. Available in 30 or 60 tablet options.

Serving Size 1 Tablet
Amount Per Tablet % Daily Value
S-Adenosyl L-Methionine (from 400 mg of S-Adenosyl L-Methionine tosylate disulfate) 200 mg *
* Daily value not established

Other Ingredients:

Microcrystalline cellulose, magnesium silicate, food glaze, magnesium stearate, stearic acid, magnesium hydroxide, glycerol, silicon dioxide, arginine, sodium alginate, and calcium oxide.

Suggested Use

1 tablet, 1 to 6 times daily on an empty stomach or as directed by a healthcare professional.

Allergy Statement

Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, and soybeans. Contains no artificial colors, flavors, or preservatives.


If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your healthcare professional before using this product.  Individuals being treated for neurological conditions, including those using prescribed medications such as antidepressants, serotonin reuptake inhibitors, and monoamine oxidase (MAO) inhibitors should consult their healthcare professional before using this product. Individuals with bipolar disorder or manic depression should not take SAMe 200 unless under medical supervision. Keep out of reach of children. 

SAMe (S-adenosylmethionine) is a natural compound made in the body from the essential amino acid L-methionine. It is involved in a number of body processes, including membrane function, neurotransmission, liver detoxification, and bone and joint health. Although SAMe can be synthesized in the body, it is dependent upon the presence of sufficient levels of other nutrients including methionine, folic acid, and vitamin B12. Dietary supplementation of SAMe is an effective way to support optimal levels of this compound.

SAMe donates methyl groups to create other compounds in a process called methylation. Methyl groups are crucial for formation of cell components including proteins, nucleic acids found in DNA and RNA, and phospholipids that form nerve cell membranes. Creatine, involved in energy production, and melatonin are also formed from SAMe. The sulfur content of SAMe is used to support synthesis of cartilage, ligaments, tendons, and bones and to form amino acids and peptides such as glutathione, cysteine, and taurine that detoxify foreign substances in the liver.

Low levels of SAMe may result in lowered serotonin levels, a brain chemical that supports mood and emotional well-being. SAMe is also required for nerve regeneration. SAMe has been shown in numerous controlled clinical trials to support healthy mood.

SAMe has been shown in animal studies to support cartilage growth and repair. In numerous human clinical trials, SAMe has demonstrated benefits for joint structure and function comparable or superior to those of other sulfur-containing nutrients such as glucosamine sulfate, chondroitin sulfate, and MSM. Research suggests that the mechanism of action behind this benefit may be due to this compound’s support of cartilage formation.

The suggested use for SAMe 200 by Klaire Labs™ is 1 tablet, 1 to 6 times daily between meals or as directed by a healthcare professional.

Klaire Labs™ provides pharmaceutical-grade, stabilized SAMe that is manufactured under low-temperature and low-humidity conditions. An enteric tablet coating, resistant to gastric acidity, helps to further ensure a biologically active product. Only SAMe products that are thus protected have demonstrated efficacy. Klaire Labs™ SAMe 200 is provided in individual foil blister-packets to maximize product stability. Each tablet contains a full 200 mg of elemental SAMe from 400 mg SAMe tosylate disulfate. Some products do not indicate the actual SAMe content, only the amount of the compound. Thus, it may be difficult to compare various products.