Endozin™

Helps protect your stomach and small intestine lining and promotes digestive comfort.^†

Zinc carnosine has been shown in multiple clinical trials to help protect the stomach lining and promote gastrointestinal comfort.^† Studies show zinc carnosine promotes healthy mucus secretion, exerts antioxidant properties, and modulates cytokine expression, thus helping protect the stomach and small intestine.^† L-glutamine promotes small intestinal cell function and mucosal integrity to further support gastric function and protect tissues.^† 

Research 

This patented, 1:1 chelate of zinc and l-carnosine provides a unique configuration that accounts for this compound's unique functions in the GI tract. Zinc-carnosine has a slow dissociation rate and adheres to the stomach lining, allowing for prolonged protection.¹ When zinc and carnosine are separated, they provide synergistic antioxidant protection, support the stomach's mucosal defenses, buffer gastric acid, and maintain healthy cytokine release.² According to studies, this combination is more effective than either ingredient alone in maintaining the integrity of the gastric lining.³ A Japanese multi-center, double-blind study involving 299 subjects found improvements in objective and subjective parameters of normal gastric health and repair, particularly after 8 weeks of daily supplementation.⁴ Seven additional clinical trials involving over 550 volunteers yielded similar results. In vitro and in vivo studies show that zinc-carnosine promotes cellular repair in the intestine by promoting healthy cell reproduction and villous function.⁵ Zinc-carnosine maintained healthy gut barrier function in a double-blind, randomized, crossover trial.⁶ This zinc-carnosine combination has been extensively researched and used in Japan, and it has an excellent safety profile. 

References 

1. Arakawa T, et al. Dig Dis Sci. 1990 May;35(5):559-66. 

2. Shimada T, et al. J Pharmacol Exp Ther. 1999 Oct;291(1):345-52. 

3. Sakae K, et al. Nutr Clin Pract. 2013 Oct;28(5):609-16. 

4. Miyoshi A, et al. Jpn Pharmacol Ther. 1992. 20;20(1):199?223. 

5. Watanabe S, et al. Aliment Pharmacol Ther. 1998 Nov;12(11):1131-8. 

6. Mahmood A, et al. Gut. 2007 Feb;56(2):168-75.