Supports healthy estrogen metabolism†
D-glucarate supports Phase II glucuronidation, a primary detoxification pathway that deactivates toxins and promotes their elimination.† D-glucarate plays a vital protective role for the immune system by inhibiting the beta-glucuronidase enzyme that can otherwise interfere with safe removal of steroid hormones such as estrogen.† Beta-glucuronidase enzymes are active throughout the body, especially in the liver, colon, lungs, skin, bladder, breast, and prostate.
|Serving Size 1 Capsule|
|Amount Per Capsule||% Daily Value|
|Calcium (as calcium D-glucarate)||60 mg||5%|
|* Daily value not established|
Vegetarian capsule (hydroxypropyl methylcellulose, water), microcrystalline cellulose, and silicon dioxide
1 capsule, 1 to 3 times daily with food or as directed by a healthcare professional.
Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, and soybeans. Contains no artificial colors, flavors, or preservatives.
If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your healthcare professional before using this product. Keep out of reach of children.
Calcium D-Glucarate is a patented form of D-glucarate (also known as D-glucaric acid), a naturally occurring substance in the body that is involved in the metabolism and disposal of toxins and excess hormones, such as estrogen. In the diet, D-glucarate is found primarily in fruits and vegetables such as apples, grapefruit, oranges, bean sprouts, and broccoli. It is also produced in small amounts in the body.
Studies show that Calcium D-Glucarate supplementation supports healthy immune function, promotes estrogen metabolism, and enhances the body’s detoxification systems through inhibition of beta-glucuronidase, an enzyme that can interfere with normal hormone metabolism.†
Upon ingestion, D-glucarate is slowly released from Calcium D-Glucarate and forms a compound that inhibits the enzyme beta-glucuronidase. This enzyme reduces the excretion of toxins and steroid hormones, including estrogen. Although beta-glucuronidase has some useful functions in the body, it can become overactive as a result of shifts in the gut microbiome, allowing toxins and hormones to be reabsorbed back into the body instead of being excreted. The slow-release nature of Calcium D-Glucarate inhibits about 50% of the enzyme activity over a five-hour period, thus helping the body to safely remove undesirable amounts of estrogen and other compounds. Because beta-glucuronidase enzymes are present in the liver, kidney, spleen, intestines, reproductive organs, and many other tissues, the beneficial actions of Calcium D-Glucarate may occur throughout the body.
Anyone concerned about assisting the body’s natural detoxifying ability can take Calcium D-Glucarate as it is a very safe, well-tolerated compound. It is especially suitable for individuals with routine exposure to environmental agents who wish to ensure an added measure of protection beyond that provided by antioxidants. Calcium D-Glucarate may be especially important for women concerned about maintaining healthy breast tissue.†
The amount needed varies between individuals. For general daily use, 1 500 mg capsule daily is sometimes recommended. Research on Calcium D-Glucarate demonstrating inhibition of beta-glucuronidease begins with amounts of 1,500 mg per day and goes up to 9 grams per day. Individuals with higher environmental exposures, or increased needs to metabolize estrogen or other hormones, can take 3 or more capsules per day. The appropriate amount will be determined by your healthcare professional.